Contains per gram powder:
Sulfadiazine …………………… 400 mg.
Trimethoprim ………………… 80 mg.
Carrier ad ………………………. 1 g.
Gastrointestinal and respiratory infections caused by trimethoprim and sulfadiazine sensitive
micro-organisms like E. coli, Haemophilus, Pasteurella, Salmonella, Staphylococcus and
Streptococcus spp. in calves, sheep, goats, poultry and swine.
The combination of trimethoprim and sulfadiazine acts synergistic and usually bactericidal
against many Gram-positive and Gram-negative bacteria like E. coli, Haemophilus, Pasteurella,
Salmonella, Staphylococcus and Streptococcus spp. Both compounds affect bacterial purine
synthesis in a different way, as a result of which a double blockade is accomplished.
Hypersensitivity to trimethoprim and/or sulphonamides.
Administration to animals with a seriously impaired renal and/or hepatic function or with blood
dyscrasias.
For oral administration:
Calves, goats and sheep: Twice daily 5 g per 100 kg body weight for 4 – 7 days.
Poultry and swine: 1 kg per 1500 – 2500 litres of drinking water for 4 – 7 days.
Note: for pre-ruminant calves, lambs and kids only.
– For meat:
Calves, sheep, goats and swine: 8 days.
Poultry: 5 days.
After long-term treatment and high dosages crystalluria can occur.
When symptoms of crystalluria occur (haematuria, kidney colic), treatment has to be stopped
immediately and for example sodium carbonate (alkalinises) has to be administered for increasing
urine solubility of sulfadiazine. Administration for a prolonged period also increases the risk for
blood dyscrasias. Anaemia, leucopenia and thrombocytopenia may also occur.
