Cattle: gastrointestinal, respiratory and intramammary infections caused by bacteria sensitive to
the combination of amoxicillin and gentamicin, such as pneumonia, diarrhoea, bacterial enteritis,
mastitis, metritis and cutaneous abscesses.
Swine: respiratory and gastrointestinal infections caused by bacteria sensitive to the combination
of amoxicillin and gentamicin, such as pneumonia, colibacillosis, diarrhoea, bacterial enteritis and
mastitis-metritis-agalactia syndrome (MMA).
The combination of amoxicillin and gentamicin acts synergistically against a wide range
of infections caused by both Gram-positive (e.g. Staphylococcus, Streptococcus and
Corynebacterium spp.) and Gram-negative (e.g. E.coli, Pasteurella, Salmonella and Pseudomonas
spp.) bacteria in cattle and swine. Amoxicillin inhibits mainly in Gram-positive bacteria the
cross-linkage between the linear peptidoglycan polymer chains that make up a major component
of the cell wall. Gentamicin binds to the 30S subunit of the ribosome of mainly Gram-negative
bacteria, thereby interrupting protein synthesis. Excretion of Biogenta occurs mainly unchanged via
urine, and to a lesser degree via milk.
Hypersensitivity towards amoxicillin or gentamicin.
Administration to animals with a seriously impaired hepatic and/or renal function.
Concurrent administration of tetracyclines, chloramphenicol, macrolides and lincosamides.
Concurrent administration of nephrotoxic compounds.
For intramuscular administration. The general dosage is 1 ml per 10 kg body weight per day for 3
days.
Cattle: 30 – 40 ml per animal per day for 3 days.
Calves: 10 – 15 ml per animal per day for 3 days.
Swine: 5 – 10 ml per animal per day for 3 days.
Piglets: 1 – 5 ml per animal per day for 3 days.
Shake well before use. Do not administer more than 20 ml in cattle or more than 10 ml in swine
and more than 5 ml in calvesper injection site to favour absorption and dispersion.
