Contains per ml:
Colistin sulphate ………………… 1 200 000 IU.
Enrofloxacin ………………………. 100 mg.
Solvents ad ………………………… 1 ml.
Coliflox Oral is indicated for gastrointestinal, respiratory and urinary tract infections caused by
colistin and enrofloxacin sensitive micro-organisms like Campylobacter, E. coli, Haemophilus,
Mycoplasma, Pasteurella and Salmonella spp. in poultry and swine.
The combination of colistin and enrofloxacin acts additive. Enrofloxacin is a synthetic, broad
spectrum antimicrobial substance, belonging to the fluoroquinoline group of antibiotics.
Enrofloxacin is active against Gram-negative and Gram-positive bacteria and mycoplasmas.
It is well absorbed after oral administration and rapidly excreted in the bile and urine, mostly
as enrofloxacin and the metabolite ciprofloxacin. Colistin is an antibiotic from the group of
polymyxins with bactericidal action against Gram-negative bacteria like E. coli, Haemophilus
and Salmonella spp. It is absorbed poorly after oral administration and serum concentrations are
generally undetectable in target species. Orally administered colistin is eliminated almost totally
in faeces.
Hypersensitivity to colistin and/or enrofloxacin or to any of the excipients.
Administration to animals with seriously impaired renal and/or hepatic functions.
Cases of resistance against quinolones and/or colistin.
Administration to poultry producing eggs for human consumption or in pregnant or lactating
animals.
Administration of Coliflox Oral in subtherapeutic doses or for prevention.
For oral administration:
Poultry: 1 litre per 2000 litres of drinking water for 3 – 5 days.
Pigs: 1 litre per 3000 litres of drinking water for 3 – 5 days.
Only sufficient medicated drinking water should be prepared to cover daily requirements.
Medicated drinking water should be replaced every 24 hours.
– For meat and offal: 9 days.
All membes of the quinolone family of antibiotics have the ability to cause articular lesions in
young animals.
Digestive alterations may appear, such as intestinal dysbiosis, accumulation of gases, mild
diarrhoea or vommiting.
Side-effects for quinolones like rash and central nervous system disturbance may occur.
During a period of rapid growth, enrofloxacin may affect joint cartilage.
